Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.57 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.50 |
| ▸ | RGS12 | O14924 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4905924 | 0.87 | EGFR (0.57) | EGFRHIF1AMAPKAPK2GSK3BCLK4 | |
| SCHEMBL4919796 | 0.83 | GSK3B (0.48) | EGFRALDH1A1MAPTHIF1AMAPKAPK2 | |
| SCHEMBL4917069 | 0.83 | EGFR (0.50) | EGFRMAPTHIF1AMAPKAPK2GSK3B | |
| SCHEMBL4599292 | 0.82 | HIF1A (0.48) | EGFRHIF1AMAPKAPK2GSK3BCLK4 | |
| SCHEMBL4906887 | 0.82 | MAPKAPK2 (0.54) | EGFRALDH1A1MAPTTDP1HIF1A | |
| SCHEMBL4916629 | 0.82 | EGFR (0.49) | EGFRMAPTHIF1AMAPKAPK2GSK3B | |
| SCHEMBL4917914 | 0.81 | EGFR (0.46) | EGFRMAPTHIF1AMAPKAPK2GSK3B | |
| SCHEMBL4914009 | 0.80 | EGFR (0.45) | EGFRMAPTHIF1AMAPKAPK2GSK3B | |
| SCHEMBL4909304 | 0.80 | EGFR (0.47) | EGFRALDH1A1MAPTHIF1AMAPKAPK2 | |
| SCHEMBL4913266 | 0.80 | ROCK2 (0.53) | EGFRMAPTHIF1AMAPKAPK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080262096-A1 | Squaric Acid Derivatives | MERCK PATENT GMBH (DE) | 2008-10-23 | — | — | US | claimed |
| EP-1838662-A1 | SQUARIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2007-10-03 | — | — | EP | claimed |
| WO-2006072354-A1 | SQUARIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2006-07-13 | — | — | WO | claimed |
| US-20080262096-A1 | Squaric Acid Derivatives | MERCK PATENT GMBH (DE) | 2008-10-23 | — | — | US | disclosed |
| EP-1838662-A1 | SQUARIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006072354-A1 | SQUARIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262096-A1 | Squaric Acid Derivatives | GLS, SGK1, PFKL | EGFR 2751/4885NOX4 2629/4885RGS12 3016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.