Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.51 |
| ▸ | MMP13 | P45452 | 4/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4614189 | 0.95 | MAOB (0.54) | MMP2MMP13MAOBBTKNR2E3 | |
| SCHEMBL4614145 | 0.91 | BTK (0.50) | MMP2MMP13MAOBBTKNR2E3 | |
| SCHEMBL1136425 | 0.89 | BTK (0.52) | MMP2MMP13MAOBBTKNR2E3 | |
| SCHEMBL1136426 | 0.89 | BTK (0.52) | MMP2MMP13MAOBBTKNR2E3 | |
| SCHEMBL13836664 | 0.84 | MMP2 (0.61) | MMP2MMP13MAOBMAPTKDM4E | |
| SCHEMBL13836663 | 0.84 | MMP2 (0.61) | MMP2MMP13MAOBMAPTKDM4E | |
| SCHEMBL8767799 | 0.84 | MMP2 (0.61) | MMP2MMP13MAOBMAPTKDM4E | |
| SCHEMBL1136434 | 0.83 | BTK (0.57) | MMP2MMP13MAOBBTKNR2E3 | |
| SCHEMBL1136433 | 0.83 | BTK (0.57) | MMP2MMP13MAOBBTKNR2E3 | |
| SCHEMBL13836049 | 0.81 | POLB (0.60) | MMP2MMP13MAOBMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919910-A1 | AZABENZIMIDAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS ANTI-CANCER AGENTS | F. Hoffmann-la Roche AG (CH) | 2008-05-14 | — | — | EP | claimed |
| WO-2007017143-A1 | AZABENZIMIDAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS ANTI-CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-15 | — | — | WO | claimed |