Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.72 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.72 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.72 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475529 | 0.86 | RXRA (0.96) | RXRANR1H2NR1H3PTGS2NR3C2 | |
| SCHEMBL3471693 | 0.84 | RXRA (1.00) | RXRANR1H2NR1H3PTGS2NR3C2 | |
| SCHEMBL3472166 | 0.84 | RXRA (0.66) | RXRANR1H2NR1H3PTGS2NR3C2 | |
| SCHEMBL3474679 | 0.84 | RXRA (1.00) | RXRANR1H2NR1H3PTGS2NR3C2 | |
| SCHEMBL3470716 | 0.83 | RXRA (0.75) | RXRANR1H2NR1H3PTGS2NR3C2 | |
| SCHEMBL3472989 | 0.83 | RXRA (0.75) | RXRANR1H2NR1H3PTGS2NR3C2 | |
| SCHEMBL3472591 | 0.83 | RXRA (0.75) | RXRANR1H2NR1H3PTGS2NR3C2 | |
| SCHEMBL3470967 | 0.82 | RXRA (0.71) | RXRANR1H2NR1H3PTGS2NR3C2 | |
| SCHEMBL8953954 | 0.78 | RXRA (0.82) | RXRANR1H2NR1H3PTGS2NR3C2 | |
| SCHEMBL3471721 | 0.77 | RXRA (1.00) | RXRANR1H2NR1H3PTGS2NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910307-A1 | PYRAZOLE BASED LXR MODULATORS | Exelixis, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007002559-A1 | PYRAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |