Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | SPTLC2 | O15270 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3471917 | 0.92 | RXRA (0.49) | RXRANR1H2NR1H3NR3C2CNR1 | |
| SCHEMBL3474805 | 0.92 | RXRA (0.47) | RXRANR1H2NR1H3NR3C2CNR1 | |
| SCHEMBL15690840 | 0.89 | CACNB4 (0.47) | RXRANR1H2NR1H3NR3C2CNR1 | |
| SCHEMBL3472556 | 0.87 | RXRA (0.51) | RXRANR1H2NR1H3NR3C2CNR1 | |
| SCHEMBL3471468 | 0.87 | RXRA (0.51) | RXRANR1H2NR1H3NR3C2CNR1 | |
| SCHEMBL3471228 | 0.86 | RXRA (0.52) | RXRANR1H2NR1H3NR3C2CNR1 | |
| SCHEMBL3473588 | 0.85 | RXRA (0.52) | RXRANR1H2NR1H3NR3C2CNR1 | |
| SCHEMBL3473811 | 0.84 | RXRA (0.51) | RXRANR1H2NR1H3NR3C2HDAC3 | |
| SCHEMBL3474517 | 0.84 | MALT1 (0.52) | RXRANR1H2NR1H3NR3C2HDAC4 | |
| SCHEMBL3473126 | 0.84 | RXRA (0.53) | RXRANR1H2NR1H3NR3C2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910307-A1 | PYRAZOLE BASED LXR MODULATORS | Exelixis, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007002559-A1 | PYRAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |