SCHEMBL459986

SCHEMBL459986

c1ccc2c(c1)Nc1ncccc1S2

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.66
GAA P10253 7/20 0.66
SMN1; SMN2 Q16637 4/20 0.66
HPGD P15428 2/20 0.66
KDM4E B2RXH2 1/20 0.66
NOX1 Q9Y5S8 10/20 0.59
ALOX15 P16050 4/20 0.59
CYP1A2 P05177 3/20 0.59
MEN1 O00255 3/20 0.59
KMT2A Q03164 3/20 0.59
SNCA P37840 3/20 0.59
BCHE P06276 2/20 0.59
ACHE P22303 2/20 0.59
TDP1 Q9NUW8 2/20 0.59
POLB P06746 1/20 0.59
CYP3A4 P08684 1/20 0.59
ADORA3 P0DMS8 1/20 0.59
ALOX12 P18054 1/20 0.59
MAOA P21397 1/20 0.59
CNR1 P21554 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30401814 1.00 MAPT (0.66) MAPTGAASMN1; SMN2HPGDKDM4E
Hydrochloric Acid SCHEMBL8317733 0.98 MAPT (0.64) MAPTGAASMN1; SMN2HPGDKDM4E
SCHEMBL25141319 0.80 NOX1 (0.61) MAPTGAASMN1; SMN2HPGDKDM4E
SCHEMBL21196533 0.80 SNCA (0.46) MAPTGAASMN1; SMN2HPGDKDM4E
SCHEMBL2575044 0.79 MAPT (1.00) MAPTGAASMN1; SMN2HPGDKDM4E
SCHEMBL2592634 0.77 ALOX15 (0.66) MAPTGAASMN1; SMN2HPGDKDM4E
Phenothiazine SCHEMBL5338471 0.77 NOX1 (0.59) MAPTGAASMN1; SMN2HPGDKDM4E
SCHEMBL6702195 0.77 MAPT (0.57) MAPTGAASMN1; SMN2HPGDKDM4E
SCHEMBL25141279 0.76 NOX1 (0.64) MAPTGAASMN1; SMN2HPGDKDM4E
SCHEMBL25141298 0.76 NOX1 (0.64) MAPTGAASMN1; SMN2HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 277 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117209508-A Azaphenothiazine compound and preparation method thereof 五邑大学 2023-12-12 CN claimed
CN-116284077-A Boron-containing azophenothiazine color-changing material and application thereof in fluoride ion detection 青海大学 2023-06-23 CN claimed
CN-107406796-B Lubricant for refrigerator and mixed composition for refrigerator 出光兴产株式会社 2020-10-16 CN claimed
EP-3279296-B1 REFRIGERATOR LUBRICATING OIL AND MIXED COMPOSITION FOR REFRIGERATOR IDEMITSU KOSAN CO (JP) 2020-04-29 EP claimed
US-10544380-B2 Refrigerator lubricating oil and mixed composition for refrigerator IDEMITSU KOSAN CO., LTD. (JP) 2020-01-28 US claimed
US-20180057766-A1 REFRIGERATOR LUBRICATING OIL AND MIXED COMPOSITION FOR REFRIGERATOR IDEMITSU KOSAN CO., LTD. (JP) 2018-03-01 US claimed
EP-3279296-A1 REFRIGERATOR LUBRICATING OIL AND MIXED COMPOSITION FOR REFRIGERATOR Idemitsu Kosan Co. Ltd (IKC) (JP) 2018-02-07 EP claimed
US-20100233244-A1 Smoking Withdrawal Combination Wafer LTS LOHMANN THERAPIE-SYSTEME AG (DE) 2010-09-16 US claimed
US-20090291123-A1 Opioid Combination Wafer LTS LOHMANN THERAPIE-SYSTEME AG (DE) 2009-11-26 US claimed
US-20090203670-A1 Combination Antidepressants Wafer LTS LOHMANN THERAPIE-SYSTEME AG (DE) 2009-08-13 US claimed
EP-1129704-A1 Process for targeted administration of active agents on the central nervous system pharmed Holding GmbH (DE) 2001-09-05 EP claimed
EP-0611757-B1 Process for the preparation of azaphenothiazines ASTA MEDICA AG (DE) 1999-01-20 EP claimed
EP-0527298-B1 Process for the preparation of pipazethate ASTA MEDICA AG (DE) 1997-07-30 EP claimed
US-5539107-A REACTION OF CHLOROPYRIDINE AND CHLOROQUINOLINES WITH MERCAPTOANILINES OR BIS/O-AMINOPHENYL DISULFIDE ASTA MEDICA AKTIENGESELLSCHAFT (DE) 1996-07-23 US claimed
EP-0611757-A1 Process for the preparation of azaphenothiazines ASTA Medica Aktiengesellschaft (DE) 1994-08-24 EP claimed
EP-0527298-A1 Process for the preparation of pipazethate ASTA Medica Aktiengesellschaft (DE) 1993-02-17 EP claimed
EP-0043469-B1 INTERFERENCE-RESISTANT TEST DEVICE FOR DETERMINING A PEROXIDATIVELY ACTIVE SUBSTANCE IN A TEST SAMPLE AND METHOD FOR PREPARING IT MILES LABORATORIES, INC. (US) 1985-01-16 EP claimed
EP-0030683-B1 TEST COMPOSITION FOR PEROXIDATIVELY ACTIVE SUBSTANCES, TEST DEVICE CONTAINING THE COMPOSITION, PROCESS FOR PREPARING SAME AND METHOD FOR THE DETERMINATION OF PEROXIDATIVELY ACTIVE SUBSTANCES MILES LABORATORIES, INC. (US) 1983-04-06 EP claimed
EP-0043469-A1 Interference-resistant test device for determining a peroxidatively active substance in a test sample and method for preparing it MILES LABORATORIES, INC. (US) 1982-01-13 EP claimed
US-4251222-A COMPRISING 10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE; FOR DIAGNOSTIC TESTS MILES LABORATORIES, INC. (US) 1981-02-17 US claimed