Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.51 |
| ▸ | OXTR | P30559 | 13/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4459186 | 0.93 | HCRTR1 (0.49) | HCRTR1HCRTR2OXTRKMT2ATAS2R14 | |
| SCHEMBL4470460 | 0.90 | HCRTR2 (0.62) | HCRTR1HCRTR2OXTRAVPR1A | |
| SCHEMBL4457211 | 0.88 | HCRTR1 (0.50) | HCRTR1HCRTR2OXTRLMNAAVPR1A | |
| SCHEMBL4459456 | 0.86 | HCRTR1 (0.49) | HCRTR1HCRTR2OXTRTAS2R14LMNA | |
| SCHEMBL4461806 | 0.84 | HCRTR2 (0.61) | HCRTR1HCRTR2OXTRAVPR1A | |
| SCHEMBL4464707 | 0.84 | KMT2A (0.52) | HCRTR1HCRTR2OXTRKMT2ALMNA | |
| SCHEMBL4457691 | 0.84 | OXTR (0.56) | HCRTR1HCRTR2OXTRKMT2ALMNA | |
| SCHEMBL4453885 | 0.84 | HCRTR2 (0.46) | HCRTR1HCRTR2OXTRTAS2R14LMNA | |
| SCHEMBL4455651 | 0.83 | HCRTR2 (0.57) | HCRTR1HCRTR2OXTRAVPR1A | |
| SCHEMBL4457194 | 0.83 | HCRTR2 (0.47) | HCRTR1HCRTR2OXTRTAS2R14LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912655-A2 | AMINOETHANE SULFONAMIDE OREXIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2008-04-23 | — | — | EP | claimed |
| WO-2007019234-A2 | AMINOETHANE SULFONAMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-02-15 | — | — | WO | claimed |