Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 3/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | APOB | P04114 | 1/20 | 0.32 |
| ▸ | MTTP | P55157 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1967111 | 0.89 | ALDH1A1 (0.41) | ALDH1A1POLBCRHR1APOBMTTP | |
| SCHEMBL1970540 | 0.82 | ALDH1A1 (0.41) | ALDH1A1USP2 | |
| SCHEMBL1971306 | 0.80 | ALDH1A1 (0.42) | ALDH1A1SCN8AUSP2 | |
| SCHEMBL1970268 | 0.80 | ALDH1A1 (0.41) | ALDH1A1CRHR1MCL1USP2 | |
| SCHEMBL1971486 | 0.77 | ALDH1A1 (0.42) | ALDH1A1POLBUSP2 | |
| SCHEMBL1969955 | 0.73 | ALDH1A1 (0.40) | ALDH1A1KCNH2MCL1USP2 | |
| SCHEMBL1969957 | 0.73 | ALDH1A1 (0.40) | ALDH1A1KCNH2MCL1USP2 | |
| SCHEMBL1973043 | 0.73 | ALDH1A1 (0.40) | ALDH1A1KCNH2MCL1USP2 | |
| SCHEMBL1970190 | 0.71 | SCN9A (0.40) | USP2 | |
| SCHEMBL1969717 | 0.70 | ALDH1A1 (0.39) | ALDH1A1POLBALPLUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937675-A2 | BICYCLIC ARYL-SULFONIC ACID [1,3,4]-THIADIAZOL-2-YL-AMIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039174-A2 | BICYCLIC ARYL-SULFONIC ACID [1,3,4]-THIADIAZOL-2-YL-AMIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (DE) | 2007-04-12 | — | — | WO | disclosed |