Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.53 |
| ▸ | CTSS | P25774 | 16/20 | 0.47 |
| ▸ | CTSK | P43235 | 15/20 | 0.47 |
| ▸ | CTSB | P07858 | 4/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3992377 | 0.89 | SCN9A (0.53) | CTSLCTSSCTSKCTSBCYP3A4 | |
| SCHEMBL268970 | 0.87 | CTSS (0.55) | CTSLCTSSCTSKCTSBSCN9A | |
| SCHEMBL31277258 | 0.85 | MAPT (0.49) | CTSLCTSSCTSKMC4RCYP3A4 | |
| SCHEMBL268217 | 0.80 | JAK3 (0.48) | CTSLCTSSCTSKMC4RCYP3A4 | |
| SCHEMBL269285 | 0.80 | CTSS (0.56) | CTSLCTSSCTSKCTSBSCN9A | |
| SCHEMBL269629 | 0.79 | MAPT (0.49) | CTSLCTSSCTSKCTSBMAPT | |
| SCHEMBL268270 | 0.79 | CTSS (0.57) | CTSLCTSSCTSKCTSBMAPT | |
| SCHEMBL4925245 | 0.79 | CTSS (0.54) | CTSLCTSSCTSKCTSB | |
| SCHEMBL6746907 | 0.77 | CTSS (0.74) | CTSLCTSSCTSKCTSB | |
| SCHEMBL3762221 | 0.77 | CTSS (0.74) | CTSLCTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912946-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | Eli Lilly and Company (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007015767-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |