Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.73 |
| ▸ | ESR2 | Q92731 | 15/20 | 0.73 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6050097 | 0.99 | ESR1 (0.72) | ESR1ESR2LTA4H | |
| SCHEMBL6050123 | 0.94 | ESR1 (0.84) | ESR1ESR2 | |
| SCHEMBL1358261 | 0.93 | ESR1 (0.80) | ESR1ESR2LTA4H | |
| SCHEMBL10306631 | 0.93 | ESR1 (0.80) | ESR1ESR2LTA4H | |
| SCHEMBL7803056 | 0.93 | ESR1 (0.66) | ESR1ESR2LTA4HBACE1 | |
| Hydrochloric Acid SCHEMBL6050311 | 0.93 | ESR1 (0.83) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL1359721 | 0.93 | ESR1 (0.79) | ESR1ESR2 | |
| SCHEMBL6050058 | 0.93 | ESR1 (0.86) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL1359377 | 0.93 | ESR1 (0.79) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL6050193 | 0.92 | ESR1 (0.65) | ESR1ESR2LTA4HBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826679-B1 | Naphthyl compounds and compositions | LILLY CO ELI (US) | 2001-11-21 | — | — | EP | claimed |
| WO-1998008797-A1 | NAPHTHYL COMPOUNDS, INTERMEDIATES, COMPOSITIONS, AND METHODS OF USE | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | claimed |
| US-20080200507-A1 | Crystalline Non-Solvated Methanesulfonic Acid Salt of 1-(4-(2-Piperidinylethoxy)Phenoxy)-2-(3-Hydroxyphenyl)-6-Hydroxynaphthalene | ELI LILLY AND COMPANY | 2008-08-21 | — | — | US | disclosed |
| US-20080200507-A1 | Crystalline Non-Solvated Methanesulfonic Acid Salt of 1-(4-(2-Piperidinylethoxy)Phenoxy)-2-(3-Hydroxyphenyl)-6-Hydroxynaphthalene | ELI LILLY AND COMPANY | 2008-08-21 | — | — | US | disclosed |
| US-20080200507-A1 | Crystalline Non-Solvated Methanesulfonic Acid Salt of 1-(4-(2-Piperidinylethoxy)Phenoxy)-2-(3-Hydroxyphenyl)-6-Hydroxynaphthalene | ELI LILLY AND COMPANY | 2008-08-21 | — | — | US | disclosed |
| EP-1912962-A2 | CRYSTALLINE NON-SOLVATED METHANESULFONIC ACID SALT OF 1-(4-(2-PIPERIDINYLETHOXY)PHENOXY)-2-(3-HYDROXYPHENYL)-6-HYDROXYNAPHTHALENE | ELI LILLY AND COMPANY (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007016139-A2 | CRYSTALLINE NON-SOLVATED METHANESULFONIC ACID SALT OF 1-(4-(2-PIPERIDINYLETHOXY)PHENOXY)-2-(3-HYDROXYPHENYL)-6-HYDROXYNAPHTHALENE | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007016139-A2 | CRYSTALLINE NON-SOLVATED METHANESULFONIC ACID SALT OF 1-(4-(2-PIPERIDINYLETHOXY)PHENOXY)-2-(3-HYDROXYPHENYL)-6-HYDROXYNAPHTHALENE | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200507-A1 | Crystalline Non-Solvated Methanesulfonic Acid Salt of 1-(4-(2-Piperidinylethoxy)Phenoxy)-2-(3-Hydroxyphenyl)-6-Hydroxynaphthalene | MPHOSPH6, HCN2, HCN1 | ESR1 4544/4885ESR2 4681/4885LTA4H 1455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.