Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.38 |
| ▸ | PIM1 | P11309 | 5/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18798864 | 0.84 | FABP3 (0.44) | MAPTGRIN3BGRIN1GRIN2C | |
| SCHEMBL1591434 | 0.82 | NTRK1 (0.33) | NTRK1PIM1MKNK1MKNK2ACVR1 | |
| SCHEMBL9208485 | 0.82 | RPS6KB1 (0.36) | NTRK1PIM1ACVR1GRIN3BGRIN1 | |
| Hydrochloric Acid SCHEMBL28042958 | 0.81 | GRIN3B (0.32) | NTRK1PIM1ACVR1GRIN3BGRIN1 | |
| SCHEMBL17251185 | 0.79 | CA12 (0.39) | TDP1MAPT | |
| SCHEMBL161321 | 0.77 | SIRT3 (0.46) | NTRK1PIM1MKNK1MKNK2ACVR1 | |
| SCHEMBL31606794 | 0.77 | SIRT3 (0.46) | NTRK1PIM1MKNK1MKNK2ACVR1 | |
| SCHEMBL5080771 | 0.77 | PDE3B (0.39) | NTRK1PIM1ACVR1GRIN3BGRIN1 | |
| SCHEMBL14857133 | 0.76 | MEN1 (0.47) | NTRK1PIM1MAPTPOLBCDC7 | |
| Hydrochloric Acid SCHEMBL5012214 | 0.76 | NTRK1 (0.44) | NTRK1PIM1MKNK1MKNK2ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912946-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | Eli Lilly and Company (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007015767-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |