SCHEMBL4602284 — predicted protein targets

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	MAPK14	Q16539	17/20	0.55

▸	MAPK13	O15264	2/20	0.53

▸	RAF1	P04049	1/20	0.53

▸	MAPT	P10636	1/20	0.51

▸	MAPK12	P53778	1/20	0.51

▸	MAPK11	Q15759	1/20	0.51

▸	EPHX2	P34913	1/20	0.51

▸	BRAF	P15056	1/20	0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4602482	0.92	MAPK14 (0.51)	MAPK14MAPK13RAF1MAPTMAPK12
SCHEMBL2957309	0.90	MAPK14 (0.47)	MAPK14MAPK13RAF1MAPTMAPK12
SCHEMBL2953552	0.90	MAPK14 (0.63)	MAPK14MAPK13RAF1MAPTMAPK12
SCHEMBL4601869	0.86	MAPK14 (0.54)	MAPK14MAPK13RAF1MAPTMAPK12
SCHEMBL4602491	0.86	MAPK14 (0.54)	MAPK14MAPK13RAF1MAPTMAPK12
SCHEMBL4604171	0.86	MAPK14 (0.61)	MAPK14MAPK13RAF1MAPTMAPK12
SCHEMBL4604062	0.85	EPHX2 (0.53)	MAPK14MAPK13RAF1MAPTMAPK12
SCHEMBL4602243	0.85	MAPK14 (0.60)	MAPK14MAPK13RAF1MAPTMAPK12
SCHEMBL4603225	0.84	MAPK14 (0.51)	MAPK14MAPK13RAF1MAPTMAPK12
SCHEMBL2951450	0.84	MAPK14 (0.59)	MAPK14MAPK13RAF1MAPTMAPK12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1761520-B1	KINASE INHIBITORS	LILLY CO ELI (US)	2008-07-09	—	—	EP	disclosed