Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4604062 | 0.90 | EPHX2 (0.53) | MAPK14MAPK13RAF1MAPTMAPK12 | |
| SCHEMBL2953552 | 0.86 | MAPK14 (0.63) | MAPK14MAPK13RAF1MAPTMAPK12 | |
| SCHEMBL4603381 | 0.85 | MAPK14 (0.51) | MAPK14MAPK13RAF1MAPTMAPK12 | |
| SCHEMBL4602284 | 0.84 | MAPK14 (0.55) | MAPK14MAPK13RAF1MAPTMAPK12 | |
| SCHEMBL4601552 | 0.84 | MAPK14 (0.55) | MAPK14MAPK13RAF1MAPTMAPK12 | |
| SCHEMBL4602243 | 0.83 | MAPK14 (0.60) | MAPK14MAPK13RAF1MAPTMAPK12 | |
| SCHEMBL4601869 | 0.83 | MAPK14 (0.54) | MAPK14MAPK13RAF1MAPTMAPK12 | |
| SCHEMBL4604171 | 0.82 | MAPK14 (0.61) | MAPK14MAPK13RAF1MAPTMAPK12 | |
| SCHEMBL4603670 | 0.82 | MAPK13 (0.53) | MAPK14MAPK13RAF1MAPTMAPK12 | |
| SCHEMBL4603262 | 0.81 | MAPK14 (0.58) | MAPK14MAPK13RAF1MAPTMAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | disclosed |