Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 17/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.67 |
| ▸ | OPRD1 | P41143 | 14/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 14/20 | 0.67 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | CCR1 | P32246 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602609 | 1.00 | OPRL1 (0.67) | OPRL1OPRM1OPRD1OPRK1CHRM4 | |
| SCHEMBL6903684 | 0.83 | CYP2D6 (0.71) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL7260277 | 0.83 | CYP2D6 (0.71) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL6676207 | 0.83 | CYP2D6 (0.71) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL6152032 | 0.83 | CYP2D6 (0.71) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL6902745 | 0.83 | CYP2D6 (0.71) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL8261399 | 0.82 | CHRM4 (0.47) | OPRL1OPRM1OPRD1OPRK1CHRM4 | |
| SCHEMBL6151725 | 0.82 | GRIN2B (0.50) | OPRL1OPRM1OPRD1OPRK1CHRM4 | |
| SCHEMBL6690779 | 0.82 | GRIN2B (0.50) | OPRL1OPRM1OPRD1OPRK1CHRM4 | |
| SCHEMBL6152148 | 0.82 | GRIN2B (0.50) | OPRL1OPRM1OPRD1OPRK1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979819-B1 | Process for the production of substituted 3-hydroxypiperidines | SPEEDEL PHARMA AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0979824-B1 | Process for the preparation of substituted piperidine-epoxides | HOFFMANN LA ROCHE (CH) | 2004-10-06 | — | — | EP | claimed |
| CN-1245800-A | Method for preparing substituted piperidine | HOFFMANN LA ROCHE (CH) | 2000-03-01 | — | — | CN | claimed |
| CN-1245805-A | Method for preparing substituted piperidine-epoxide | HOFFMANN LA ROCHE (CH) | 2000-03-01 | — | — | CN | claimed |
| EP-0979824-A1 | Process for the preparation of substituted piperidine-epoxides | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | claimed |
| EP-0979819-A1 | Process for the production of substituted 3-hydroxypiperidines | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | claimed |
| EP-0979819-B1 | Process for the production of substituted 3-hydroxypiperidines | SPEEDEL PHARMA AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| EP-0979824-B1 | Process for the preparation of substituted piperidine-epoxides | HOFFMANN LA ROCHE (CH) | 2004-10-06 | — | — | EP | disclosed |
| CN-1161335-C | Method for preparing substituted piperidine | - | 2004-08-11 | — | — | CN | disclosed |
| CN-1111534-C | Method for preparing substituted piperidine-epoxide | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | CN | disclosed |
| US-6274735-B1 | RENIN INHIBITORS | HOFFMANN-LA ROCHE INC. | 2001-08-14 | — | — | US | disclosed |
| US-6268499-B1 | USEFUL AS RENIN INHIBITORS | HOFFMAN-LA ROCHE INC. | 2001-07-31 | — | — | US | disclosed |
| CN-1245805-A | Method for preparing substituted piperidine-epoxide | HOFFMANN LA ROCHE (CH) | 2000-03-01 | — | — | CN | disclosed |
| CN-1245800-A | Method for preparing substituted piperidine | HOFFMANN LA ROCHE (CH) | 2000-03-01 | — | — | CN | disclosed |
| EP-0979824-A1 | Process for the preparation of substituted piperidine-epoxides | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | disclosed |
| EP-0979819-A1 | Process for the production of substituted 3-hydroxypiperidines | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | disclosed |