Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 8/20 | 0.64 |
| ▸ | HTR3A | P46098 | 4/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL492754 | 1.00 | CHRNA7 (0.64) | CHRNA7HTR3AKCNH2HRH1CCR3 | |
| SCHEMBL491613 | 0.95 | CHRNA7 (0.62) | CHRNA7HTR3ANTRK1HTR3EHTR3B | |
| SCHEMBL1966113 | 0.93 | CHRNA7 (0.64) | CHRNA7HTR3AKCNH2NTRK1HTR3E | |
| SCHEMBL492223 | 0.93 | CHRNA7 (0.64) | CHRNA7HTR3AKCNH2NTRK1HTR3E | |
| SCHEMBL492823 | 0.87 | CHRNA7 (0.64) | CHRNA7HTR3A | |
| SCHEMBL4606106 | 0.87 | CHRNA7 (0.64) | CHRNA7HTR3A | |
| SCHEMBL1963239 | 0.85 | CHRNA7 (0.70) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL1963670 | 0.85 | CHRNA7 (0.70) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL1964032 | 0.85 | CHRNA7 (0.66) | CHRNA7HTR3AKCNH2 | |
| SCHEMBL1966222 | 0.85 | CHRNA7 (0.66) | CHRNA7HTR3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940833-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF | Memory Pharmaceuticals Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007038367-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |