Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 16/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5642201 | 0.87 | F10 (0.48) | F10F2MAPTLMNA | |
| SCHEMBL4604856 | 0.84 | CHRNA7 (0.42) | F10F2MAPTLMNAPRMT5 | |
| SCHEMBL4605200 | 0.84 | PRMT5 (0.39) | F10F2MAPTLMNAKDM4E | |
| SCHEMBL4594596 | 0.77 | LMNA (0.39) | F10MAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL4603427 | 0.77 | F10 (0.39) | F10F2LMNAKDM4EALDH1A1 | |
| SCHEMBL4603648 | 0.76 | LMNA (0.41) | F10MAPTLMNAPRMT5 | |
| SCHEMBL1993627 | 0.75 | F10 (0.66) | F10F2MAPT | |
| SCHEMBL1999163 | 0.75 | F10 (0.68) | F10F2MAPT | |
| SCHEMBL4587961 | 0.75 | F10 (0.47) | F10F2MAPTLMNA | |
| SCHEMBL5638175 | 0.73 | F10 (0.40) | F10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667647-A4 | MONOCYCLIC AND BICYCLIC LACTAMS AS FACTOR XA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1667647-A2 | MONOCYCLIC AND BICYCLIC LACTAMS AS FACTOR XA INHIBITORS | Bristol-Myers Squibb Company (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005032468-A2 | MONOCYCLIC AND BICYCLIC LACTAMS AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-04-14 | — | — | WO | disclosed |