Known targets — ChEMBL curated mechanism
GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BM
The experimentally established mechanism targets of Amantadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 known ✓ | Q05586 | 6/20 | 0.81 |
| ▸ | GRIN2A known ✓ | Q12879 | 6/20 | 0.81 |
| ▸ | GRIN2D known ✓ | O15399 | 5/20 | 0.81 |
| ▸ | GRIN3B known ✓ | O60391 | 5/20 | 0.81 |
| ▸ | GRIN2B known ✓ | Q13224 | 5/20 | 0.81 |
| ▸ | GRIN2C known ✓ | Q14957 | 5/20 | 0.81 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 5/20 | 0.81 |
| ▸ | LMNA | P02545 | 4/20 | 0.81 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.81 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.81 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.81 |
| ▸ | TSHR | P16473 | 1/20 | 0.81 |
| ▸ | STAT6 | P42226 | 1/20 | 0.81 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.81 |
| ▸ | THRB | P10828 | 2/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.77 |
| ▸ | BLM | P54132 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amantadine SCHEMBL29011286 | 0.90 | GRIN1 (0.87) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL20409394 | 0.90 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL15672299 | 0.90 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL21309814 | 0.90 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL3642447 | 0.90 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL15532073 | 0.90 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL4098 | 0.90 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL21310017 | 0.90 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL23859927 | 0.87 | GRIN1 (0.93) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL21192810 | 0.87 | GRIN1 (0.93) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118344310-A | Compound, preparation method, lipid nanoparticle thereof and pharmaceutical composition | 苏州慧疗生物医药科技有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-111166730-A | Quick-release orally-dissolvable film of amantadine hydrochloride and preparation method and application thereof | 杨守忠 | 2020-05-19 | — | — | CN | disclosed |
| CN-108120652-A | A kind of preparation method of amantadine molecular engram film piezoelectric transducer | 天津科技大学 | 2018-06-05 | — | — | CN | disclosed |
| WO-2008049615-A1 | USE OF VITAMINS IN FERMENTATION PROCESSES FOR THE PRODUCTION OF AMINO ACIDS | DSM IP ASSETS B.V. (NL) | 2008-05-02 | — | — | WO | disclosed |
| EP-1916308-A1 | Use of vitamins in fermentation processes for the production of amino acids | DSMIP Assets B.V. (NL) | 2008-04-30 | — | — | EP | disclosed |