Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 17/20 | 0.54 |
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6041283 | 1.00 | REN (0.54) | RENCSF1RPDE4B | |
| SCHEMBL7081003 | 0.91 | REN (0.53) | RENCSF1R | |
| SCHEMBL4603573 | 0.91 | REN (0.53) | RENCSF1R | |
| SCHEMBL6042551 | 0.90 | REN (0.58) | RENPDE4B | |
| SCHEMBL6041844 | 0.90 | REN (0.48) | RENCSF1RPDE4B | |
| SCHEMBL4603165 | 0.88 | REN (0.53) | RENPDE4B | |
| SCHEMBL6043932 | 0.88 | REN (0.53) | RENPDE4B | |
| SCHEMBL5555749 | 0.85 | REN (0.66) | RENPDE4B | |
| SCHEMBL4601723 | 0.85 | REN (0.66) | RENPDE4B | |
| SCHEMBL3413294 | 0.84 | REN (0.51) | RENPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979819-B1 | Process for the production of substituted 3-hydroxypiperidines | SPEEDEL PHARMA AG (CH) | 2008-04-23 | — | — | EP | claimed |
| WO-2000063173-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PIPERIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-10-26 | — | — | WO | claimed |
| EP-0979819-A1 | Process for the production of substituted 3-hydroxypiperidines | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | claimed |
| EP-0979819-B1 | Process for the production of substituted 3-hydroxypiperidines | SPEEDEL PHARMA AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| US-6274735-B1 | RENIN INHIBITORS | HOFFMANN-LA ROCHE INC. | 2001-08-14 | — | — | US | disclosed |
| WO-2000063173-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PIPERIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-10-26 | — | — | WO | disclosed |
| EP-0979819-A1 | Process for the production of substituted 3-hydroxypiperidines | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | disclosed |