Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.47 |
| ▸ | ADH1B | P00325 | 1/20 | 0.47 |
| ▸ | ADH1C | P00326 | 1/20 | 0.47 |
| ▸ | ADH1A | P07327 | 1/20 | 0.47 |
| ▸ | ADH7 | P40394 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL156664 | 0.83 | MEN1 (0.56) | MEN1KMT2ATDP1HDAC8ALDH1A1 | |
| SCHEMBL5181873 | 0.83 | THRB (0.56) | MEN1KMT2ATDP1HDAC8ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1252387 | 0.81 | MEN1 (0.54) | MEN1KMT2ATDP1HDAC8ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL27486735 | 0.81 | MEN1 (0.54) | MEN1KMT2ATDP1HDAC8ALDH1A1 | |
| Bicarbonate SCHEMBL23420914 | 0.80 | HDAC8 (0.64) | MEN1KMT2ATDP1HDAC8HDAC6 | |
| Bicarbonate SCHEMBL11577277 | 0.80 | HDAC8 (0.64) | MEN1KMT2ATDP1HDAC8HDAC6 | |
| SCHEMBL87424 | 0.79 | SPHK2 (0.65) | MEN1KMT2ATDP1HDAC8ALDH1A1 | |
| SCHEMBL12809838 | 0.79 | MEN1 (0.52) | MEN1KMT2ATDP1HDAC8ALDH1A1 | |
| SCHEMBL4939366 | 0.79 | MEN1 (0.52) | MEN1KMT2ATDP1HDAC8ALDH1A1 | |
| SCHEMBL4589304 | 0.79 | EPHX1 (0.61) | MEN1KMT2ATP53GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768978-B1 | 2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-07-09 | — | — | EP | disclosed |
| US-20080058332-A1 | 2,4,6-Trisubstituted Pyrimidines as Phosphotidylinositol (Pi) 3-Kinase Inhibitors and Their Use in the Treatment of Cancer | ASTRAZENECA AB (SE) | 2008-03-06 | — | — | US | disclosed |
| EP-0154490-B1 | PROCESS FOR THE PREPARATION OF PYRROLIDONE DERIVATIVES | I.S.F. Socièta per Azioni (IT) | 1988-08-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058332-A1 | 2,4,6-Trisubstituted Pyrimidines as Phosphotidylinositol (Pi) 3-Kinase Inhibitors and Their Use in the Treatment of Cancer | PIK3CA, TYMP, PIK3CB | MEN1 2387/4885KMT2A 2088/4885TDP1 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.