Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 9/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL492632 | 0.84 | NOTUM (0.37) | NOTUMMCHR1IDH1JAK3CHRM4 | |
| SCHEMBL14542488 | 0.79 | NOTUM (0.37) | NOTUMMCHR1IDH1JAK3USP28 | |
| SCHEMBL4603926 | 0.75 | NTSR1 (0.41) | IDH1 | |
| SCHEMBL492491 | 0.73 | CHRNA7 (0.41) | — | |
| SCHEMBL492153 | 0.73 | CHRNA7 (0.41) | — | |
| SCHEMBL24681680 | 0.71 | MCHR1 (0.44) | NOTUMMCHR1CHRM4 | |
| SCHEMBL492049 | 0.68 | MCHR1 (0.43) | MCHR1USP28 | |
| SCHEMBL492199 | 0.68 | MCHR1 (0.43) | MCHR1USP28 | |
| SCHEMBL492284 | 0.64 | PDE10A (0.42) | MCHR1JAK3 | |
| SCHEMBL20896254 | 0.64 | MCHR1 (0.46) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940833-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF | Memory Pharmaceuticals Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007038367-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |