Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4603231 | 0.95 | LMNA (0.52) | NTRK1MAPK14LMNAMAPK13MAPK12 | |
| SCHEMBL4601552 | 0.91 | MAPK14 (0.55) | NTRK1MAPK14LMNAMAPK13MAPK12 | |
| SCHEMBL4602559 | 0.90 | LMNA (0.49) | NTRK1MAPK14LMNAMAPK13MAPK12 | |
| SCHEMBL4602968 | 0.89 | MAPK14 (0.52) | NTRK1MAPK14LMNAMAPK13MAPK12 | |
| SCHEMBL4603544 | 0.89 | MAPK14 (0.51) | NTRK1MAPK14LMNAMAPK13MAPK12 | |
| SCHEMBL2957016 | 0.88 | MAPT (0.48) | NTRK1MAPK14LMNAMAPK13MAPK12 | |
| SCHEMBL2960137 | 0.88 | MAPK14 (0.55) | MAPK14LMNAMAPK13MAPK12MAPK11 | |
| SCHEMBL4603425 | 0.87 | MAPK14 (0.57) | NTRK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2957789 | 0.86 | LMNA (0.49) | MAPK14LMNAMAPK13MAPK12MAPK11 | |
| SCHEMBL4603660 | 0.85 | BRAF (0.51) | NTRK1MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | disclosed |