Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | GRM5 | P41594 | 3/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14141142 | 1.00 | MAPT (0.62) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL4605058 | 0.91 | TGFBR1 (0.53) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL4606194 | 0.90 | TGFBR1 (0.58) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL13166071 | 0.90 | MAPT (0.59) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL4604313 | 0.90 | MEN1 (0.63) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3354342 | 0.90 | MAPT (0.59) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL4606456 | 0.89 | TGFBR1 (0.70) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3565780 | 0.89 | MEN1 (0.59) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL4604442 | 0.88 | TGFBR1 (0.58) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL4604198 | 0.88 | TGFBR1 (0.58) | MAPTMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753512-B1 | TETRAHYDROPYRIDOTHIOPHENES | NYCOMED GMBH (DE) | 2008-07-09 | — | — | EP | claimed |