Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1307213 | 0.81 | HSD17B10 (1.00) | SMN1; SMN2KDM4EHSD17B10TSHRRAB9A | |
| SCHEMBL15120766 | 0.79 | HSD17B10 (0.68) | SMN1; SMN2KDM4EHSD17B10TSHRRAB9A | |
| SCHEMBL2678509 | 0.79 | HSD17B10 (0.56) | SMN1; SMN2KDM4EHSD17B10TSHRRAB9A | |
| SCHEMBL2678590 | 0.79 | HSD17B10 (0.56) | SMN1; SMN2KDM4EHSD17B10TSHRRAB9A | |
| SCHEMBL2678505 | 0.79 | HSD17B10 (0.56) | SMN1; SMN2KDM4EHSD17B10TSHRRAB9A | |
| SCHEMBL11729230 | 0.77 | ALDH1A1 (0.66) | SMN1; SMN2KDM4EHSD17B10POLBALDH1A1 | |
| SCHEMBL11734795 | 0.77 | ALDH1A1 (0.70) | SMN1; SMN2KDM4EHSD17B10TSHRALDH1A1 | |
| SCHEMBL16404476 | 0.77 | ALDH1A1 (0.60) | KDM4EHSD17B10ALDH1A1HPGDGAA | |
| SCHEMBL28170369 | 0.77 | ALDH1A1 (0.60) | KDM4EHSD17B10ALDH1A1HPGDGAA | |
| SCHEMBL14963912 | 0.76 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EHSD17B10TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940792-A2 | AMINOPYRIMIDINE, AMINOPYRIDINE AND ANILINE DERIVATIVES INHIBITORS OF PIM-1 AND/OR PIM-3 | Exelixis, Inc. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007044724-A2 | AMINOPYRIMIDINE, AMINOPYRIDINE AND ANILINE DERIVATIVES INHIBITORS OF PIM-I AND/OR PIM-3 | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |