Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1002272 | 0.75 | PARP1 (0.38) | PARP1PIK3CDPIK3CAPIK3CGBRD4 | |
| SCHEMBL1000891 | 0.74 | PARP1 (0.45) | PARP1PIK3CDPIK3CAPIK3CGBRD4 | |
| SCHEMBL5243321 | 0.73 | PARP1 (0.39) | PARP1PIK3CDPIK3CAPIK3CGMAPK1 | |
| SCHEMBL1002883 | 0.69 | PARP1 (0.47) | PARP1PIK3CDPIK3CAPIK3CGBRD4 | |
| SCHEMBL1005115 | 0.68 | PARP1 (0.45) | PARP1PIK3CDPIK3CAPIK3CGBRD4 | |
| SCHEMBL1002269 | 0.68 | PARP1 (0.43) | PARP1PIK3CDPIK3CAPIK3CGMAPK1 | |
| SCHEMBL1003205 | 0.66 | PARP1 (0.39) | PARP1PARP2 | |
| SCHEMBL1005065 | 0.66 | PARP1 (0.37) | PARP1PIK3CDPIK3CAPIK3CGPARP2 | |
| SCHEMBL1001401 | 0.66 | ITGB3 (0.35) | PARP1PARP2ITGB3ITGA2B | |
| SCHEMBL1001568 | 0.64 | PIK3CD (0.42) | PARP1PIK3CDPIK3CAPIK3CGBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912940-A1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | AstraZeneca AB (SE) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007021309-A1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | WO | disclosed |