Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 19/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.39 |
| ▸ | SOAT2 | O75908 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL460439 | 1.00 | DGAT1 (0.48) | DGAT1KDM4EMEN1NPC1GAA | |
| SCHEMBL463587 | 0.88 | DGAT1 (0.44) | DGAT1SOAT1SOAT2 | |
| SCHEMBL463588 | 0.88 | DGAT1 (0.44) | DGAT1SOAT1SOAT2 | |
| SCHEMBL10197577 | 0.80 | DGAT1 (0.47) | DGAT1SOAT1SOAT2 | |
| SCHEMBL10197596 | 0.79 | DGAT1 (0.40) | DGAT1SOAT1SOAT2 | |
| SCHEMBL10197621 | 0.78 | DGAT1 (0.42) | DGAT1SOAT1SOAT2 | |
| SCHEMBL902024 | 0.78 | DGAT1 (0.43) | DGAT1NPC1MAPTSOAT1 | |
| SCHEMBL383971 | 0.77 | DGAT1 (0.84) | DGAT1SOAT1SOAT2 | |
| SCHEMBL384295 | 0.77 | DGAT1 (0.73) | DGAT1SOAT1SOAT2 | |
| SCHEMBL383972 | 0.77 | DGAT1 (0.84) | DGAT1SOAT1SOAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408744-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Schering Corporation (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010107768-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |