Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 3/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13261204 | 0.80 | MAPT (0.49) | KDM4EPLAUTDP1AHRALDH1A1 | |
| SCHEMBL11574148 | 0.80 | KDM4E (0.68) | KDM4EAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL566358 | 0.78 | PLAU (0.70) | PLAUTDP1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL423692 | 0.78 | ACLY (0.56) | KDM4EAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL30084374 | 0.78 | ACLY (0.56) | KDM4EAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL28329497 | 0.77 | KMT2A (0.49) | KDM4EALDH1A1SMN1; SMN2TP53TSHR | |
| SCHEMBL27826289 | 0.77 | PLAU (0.41) | KDM4EDHODHPLAUTDP1ALDH1A1 | |
| SCHEMBL15391451 | 0.76 | KDM4E (0.48) | KDM4EAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL10722355 | 0.76 | AKR1C4 (0.50) | KDM4EAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL27747426 | 0.76 | KMT2A (0.44) | KDM4EDHODHALDH1A1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940796-A1 | ISOQUINOLINES DERIVATIVES AS IGF-1R INHIBITORS | Analytecon S.A. (CH) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007029107-A1 | ISOQUINOLINES DERIVATIVES AS IGF-1R INHIBITORS | ANALYTECON SA (CH) | 2007-03-15 | — | — | WO | disclosed |