Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | BRAF | P15056 | 5/20 | 0.45 |
| ▸ | RAF1 | P04049 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2961551 | 0.88 | MAPK14 (0.43) | MAPK14BRAFRAF1LMNAMAPK13 | |
| SCHEMBL4602968 | 0.86 | MAPK14 (0.52) | MAPK14NTRK1BRAFRAF1LMNA | |
| SCHEMBL4602454 | 0.86 | MAPK14 (0.52) | MAPK14NTRK1BRAFRAF1LMNA | |
| SCHEMBL4603425 | 0.85 | MAPK14 (0.57) | MAPK14NTRK1BRAFRAF1MAPK13 | |
| SCHEMBL4604914 | 0.85 | MAPK14 (0.49) | MAPK14NTRK1BRAFRAF1LMNA | |
| SCHEMBL4603229 | 0.84 | MAPK14 (0.50) | MAPK14NTRK1BRAFRAF1LMNA | |
| SCHEMBL4602482 | 0.84 | MAPK14 (0.51) | MAPK14NTRK1BRAFRAF1MAPK13 | |
| SCHEMBL4603544 | 0.84 | MAPK14 (0.51) | MAPK14NTRK1BRAFRAF1LMNA | |
| SCHEMBL4603231 | 0.84 | LMNA (0.52) | MAPK14NTRK1BRAFRAF1LMNA | |
| SCHEMBL4602985 | 0.84 | MAPK14 (0.49) | MAPK14NTRK1BRAFRAF1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | disclosed |