Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 10/20 | 0.69 |
| ▸ | PPARA | Q07869 | 3/20 | 0.69 |
| ▸ | PPARG | P37231 | 1/20 | 0.67 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21991483 | 0.88 | MAOB (0.63) | PPARAPPARGADAMTS4MMP13FFAR1 | |
| SCHEMBL25212758 | 0.81 | CYP1A2 (0.59) | PPARDPPARAPPARGCYP1A2GAA | |
| SCHEMBL21057241 | 0.81 | CYP1A2 (0.59) | PPARDPPARAPPARGCYP1A2GAA | |
| SCHEMBL11597291 | 0.81 | CYP1A2 (0.59) | PPARDPPARAPPARGCYP1A2GAA | |
| SCHEMBL10946026 | 0.77 | CYP1A2 (0.51) | PPARDPPARAPPARGCYP1A2GAA | |
| SCHEMBL8089170 | 0.77 | CYP1A2 (0.54) | PPARDPPARAPPARGCYP1A2GAA | |
| SCHEMBL136831 | 0.77 | CYP1A2 (0.54) | PPARDPPARAPPARGCYP1A2GAA | |
| SCHEMBL8089167 | 0.77 | CYP1A2 (0.54) | PPARDPPARAPPARGCYP1A2GAA | |
| SCHEMBL11355228 | 0.77 | CYP1A2 (0.49) | PPARDPPARAMMP13PSEN1PSEN2 | |
| SCHEMBL1744700 | 0.77 | CYP1A2 (0.64) | PPARDPPARAPPARGFFAR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756062-A4 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2008-01-02 | — | — | EP | disclosed |
| EP-1756062-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005113506-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2005-12-01 | — | — | WO | disclosed |