SCHEMBL4604750

SCHEMBL4604750

CCCCCc1ccc(-c2ccccc2)c(-c2ccc(C#N)cc2)c1

nearest known ligand 0.62

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.62
HSD17B10 Q99714 1/20 0.62
PSMB5 P28074 1/20 0.46
HSD11B1 P28845 2/20 0.45
GPR3 P46089 1/20 0.44
LTB4R2 Q9NPC1 1/20 0.43
RARB P10826 2/20 0.42
HRH3 Q9Y5N1 2/20 0.41
CYP19A1 P11511 3/20 0.41
KDM1A O60341 2/20 0.41
CYP2A6 P11509 1/20 0.40
ABCB1 P08183 1/20 0.40
ABCG2 Q9UNQ0 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4651878 1.00 TSHR (0.62) TSHRHSD17B10PSMB5HSD11B1GPR3
SCHEMBL30266947 1.00 TSHR (0.62) TSHRHSD17B10PSMB5HSD11B1GPR3
SCHEMBL4603532 0.99 TSHR (0.65) TSHRHSD17B10PSMB5HSD11B1GPR3
SCHEMBL11730491 0.99 TSHR (0.65) TSHRHSD17B10PSMB5HSD11B1GPR3
SCHEMBL9632643 0.99 TSHR (0.65) TSHRHSD17B10PSMB5HSD11B1GPR3
SCHEMBL11572123 0.99 TSHR (0.65) TSHRHSD17B10PSMB5HSD11B1GPR3
SCHEMBL4605460 0.99 TSHR (0.65) TSHRHSD17B10PSMB5HSD11B1GPR3
SCHEMBL3854168 0.92 TSHR (0.62) TSHRHSD17B10PSMB5HSD11B1GPR3
SCHEMBL7208756 0.92 TSHR (0.62) TSHRHSD17B10PSMB5HSD11B1GPR3
SCHEMBL11339892 0.91 TSHR (0.65) TSHRHSD17B10HSD11B1GPR3RARB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1680482-B1 SILICONE COMPOSITION AND POLYMER DISPERSED LIQUID CRYSTAL DOW CORNING (US) 2008-10-08 EP disclosed
EP-1682632-B1 SILICONE COMPOSITION AND POLYMER DISPERSED LIQUID CRYSTAL DOW CORNING (US) 2008-07-09 EP disclosed
US-20070003702-A1 Method of preparing a metal-silicone rubber composite DOW CORNING CORPORATION 2007-01-04 US disclosed
EP-1689906-A1 METHOD OF PREPARING A METAL-SILICONE RUBBER COMPOSITE Dow Corning Corporation (US) 2006-08-16 EP disclosed
EP-1682632-A1 SILICONE COMPOSITION AND POLYMER DISPERSED LIQUID CRYSTAL Dow Corning Corporation (US) 2006-07-26 EP disclosed
EP-1680482-A1 SILICONE COMPOSITION AND POLYMER DISPERSED LIQUID CRYSTAL Dow Corning Corporation (US) 2006-07-19 EP disclosed
WO-2005056871-A1 METHOD OF PREPARING A METAL-SILICONE RUBBER COMPOSITE DOW CORNING CORPORATION (US) 2005-06-23 WO disclosed
WO-2005044949-A1 SILICONE COMPOSITION AND POLYMER DISPERSED LIQUID CRYSTAL DOW CORNING CORPORATION (US) 2005-05-19 WO disclosed
WO-2005044950-A1 SILICONE COMPOSITION AND POLYMER DISPERSED LIQUID CRYSTAL DOW CORNING CORPORATION (US) 2005-05-19 WO disclosed
US-6682661-B2 BETWEEN 2 ELECTRODE LAYERS, CONTAINS A POLYMER DISPERSED LIQUID CRYSTAL FILM, CONSISTS OF A LIQUID CRYSTAL MIXTURE FORMING MICRODROPLETS IN AN OPTICALLY ISOTROPIC, TRANSPARENT POLYMER MATRIX, EXHIBITS ELECTRICALLY SWITCHABLE TRANSPARENCY MERCK PATENT GESELLSCHAFT (DE) 2004-01-27 US disclosed
EP-0261165-A1 LIQUID CRYSTAL DISPLAYS AND FLUORESCENT DYES FOR USE THEREIN. GEN ELECTRIC CO PLC (GB) 1988-03-30 EP disclosed
WO-1987005617-A1 LIQUID CRYSTAL DISPLAYS AND FLUORESCENT DYES FOR USE THEREIN THE GENERAL ELECTRIC COMPANY, P.L.C. (GB) 1987-09-24 WO disclosed
WO-1987005617-A1 LIQUID CRYSTAL DISPLAYS AND FLUORESCENT DYES FOR USE THEREIN THE GENERAL ELECTRIC COMPANY, P.L.C. (GB) 1987-09-24 WO disclosed
EP-0074608-B1 LIQUID CRYSTAL HALOGEN COMPOUNDS, PROCESS FOR THEIR PREPARATION, DIELECTRIC AND DECTROOPTICAL DISPLAY ELEMENT CONTAINING THEM MERCK PATENT GmbH (DE) 1985-07-03 EP disclosed
US-4490305-A Liquid-crystalline halogen compounds, process for their preparation, dielectrics containing these, and electro-optical display element MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1984-12-25 US disclosed
US-4456545-A Dichroitic anthraquinone dyestuffs useful in liquid crystalline dielectrics and electro-optical indicator elements MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1984-06-26 US disclosed
US-4391754-A Anthraquinone compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-07-05 US disclosed
EP-0074608-A2 Liquid crystal halogen compounds, process for their preparation, dielectric and dectrooptical display element containing them MERCK PATENT GmbH (DE) 1983-03-23 EP disclosed
US-4285829-A Liquid-crystalline dielectric MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1981-08-25 US disclosed
US-4017416-A P-cyanophenyl 4-alkyl-4'-biphenylcarboxylate, method for preparing same and liquid crystal compositions using same CHISSO CORPORATION (JA) 1977-04-12 US disclosed