Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.49 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4604755 | 1.00 | SLC18A3 (0.49) | SLC18A3GRIA4HTR2AHTR2CHTR2B | |
| SCHEMBL4604751 | 1.00 | SLC18A3 (0.49) | SLC18A3GRIA4HTR2AHTR2CHTR2B | |
| SCHEMBL1138540 | 0.96 | SLC18A3 (0.53) | SLC18A3GRIA4HTR2AHTR2CHTR2B | |
| SCHEMBL11476408 | 0.86 | SLC18A3 (0.45) | SLC18A3GRIA4HTR2AHTR2CHTR2B | |
| SCHEMBL11482654 | 0.81 | SLC6A2 (0.47) | SLC18A3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL25341890 | 0.79 | SLC18A3 (0.49) | SLC18A3GRIA4HTR2AHTR2CHTR2B | |
| SCHEMBL4607615 | 0.79 | KDM1A (0.47) | GRIA4HTR2CHTR2BAR | |
| SCHEMBL8326083 | 0.79 | KDM1A (0.47) | SLC18A3HTR2AHTR2CHTR2BAR | |
| SCHEMBL31513775 | 0.79 | SLC18A3 (0.49) | SLC18A3GRIA4HTR2AHTR2CHTR2B | |
| SCHEMBL4606519 | 0.79 | KDM1A (0.47) | GRIA4HTR2CHTR2BAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |
| EP-1246797-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001042203-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |