Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 17/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 16/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896599 | 0.81 | CYP11B2 (0.63) | CYP11B2CYP11B1CYP19A1ADRA2BCYP3A4 | |
| SCHEMBL461638 | 0.78 | CYP11B2 (0.63) | CYP11B2CYP11B1CYP19A1ADRA2BCYP3A4 | |
| SCHEMBL10175355 | 0.78 | CYP11B2 (0.50) | CYP11B2CYP11B1CYP19A1ADRA2BRAB9A | |
| SCHEMBL17896681 | 0.78 | CYP11B2 (0.59) | CYP11B2CYP11B1CYP19A1ADRA2BCYP3A4 | |
| SCHEMBL17896682 | 0.78 | CYP11B2 (0.63) | CYP11B2CYP11B1CYP19A1ADRA2BCYP3A4 | |
| SCHEMBL459353 | 0.74 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP19A1ADRA2BCYP3A4 | |
| SCHEMBL10175357 | 0.74 | CYP11B2 (0.44) | CYP11B2CYP11B1CYP19A1ADRA2BCYP3A4 | |
| SCHEMBL459504 | 0.73 | CYP11B2 (0.56) | CYP11B2CYP11B1CYP19A1ADRA2BTLR7 | |
| SCHEMBL17883792 | 0.72 | CYP11B2 (0.58) | CYP11B2CYP11B1CYP19A1ADRA2BCYP3A4 | |
| SCHEMBL17896676 | 0.71 | CYP11B1 (0.68) | CYP11B2CYP11B1CYP19A1ADRA2BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| EP-2595482-A1 | ALDOSTERONE SYNTHASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |