SCHEMBL4605501

SCHEMBL4605501

CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(NS(=O)(=O)CCCO)c(C3CC3)cc12

nearest known ligand 0.53

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 5/20 0.53
CYP3A4 P08684 5/20 0.53
CYP2C19 P33261 4/20 0.53
KCNH2 Q12809 2/20 0.52
CYP2C8 P10632 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19875962 0.93 CYP2C9 (0.52) CYP2C9CYP3A4CYP2C19KCNH2
SCHEMBL2302055 0.90 CYP2C9 (0.56) CYP2C9CYP3A4CYP2C19KCNH2CYP2C8
SCHEMBL19876006 0.90 CYP2C9 (0.52) CYP2C9CYP3A4CYP2C19KCNH2CYP2C8
SCHEMBL2296829 0.88 CYP2C9 (0.52) CYP2C9CYP3A4CYP2C19KCNH2
SCHEMBL18095429 0.88 CYP2C9 (0.52) CYP2C9CYP3A4CYP2C19KCNH2
SCHEMBL19876050 0.88 CYP2C9 (0.49) CYP2C9CYP3A4CYP2C19KCNH2
SCHEMBL4304089 0.87 CYP2C9 (0.54) CYP2C9CYP3A4CYP2C19KCNH2CYP2C8
SCHEMBL6119957 0.87 CYP2C9 (0.54) CYP2C9CYP3A4CYP2C19KCNH2CYP2C8
SCHEMBL14697885 0.87 CYP2C9 (0.55) CYP2C9CYP3A4CYP2C19KCNH2CYP2C8
SCHEMBL2298808 0.87 CYP2C9 (0.59) CYP2C9CYP3A4CYP2C19KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1945623-A2 POLYMORPHS OF 5-CYCLOPROPYL-2-(4-FLUOROPHENYL)-6-[(2-HYDROXYETHYL)(METHYLSULFONYL) AMINO]-N-METHYL-1-BENZOFURAN-3-CARBOXAMIDE AND METHODS OF MAKING THE SAME Wyeth a Corporation of the State of Delaware (US) 2008-07-23 EP claimed
WO-2007059421-A2 POLYMORPHS OF 5-CYCLOPROPYL-2-(4-FLUOROPHENYL)-6-[(2-HYDROXYETHYL)(METHYLSULFONYL) AMINO]-N-METHYL-1-BENZOFURAN-3-CARBOXAMIDE AND METHODS OF MAKING THE SAME WYETH (US) 2007-05-24 WO claimed
EP-1948137-A2 PHARMACEUTICAL FORMULATIONS CONTAINING 5-CYCLOPROPYL-2(4-FLUOROPHENYL)-6-(2-HYDROXYETHYL)(METHYLSULFONYL) AMINO-N-METHYL-1-BENZOFURAN-3-CARBOXAMIDE AND METHOD OF MAKING SAME Wyeth a Corporation of the State of Delaware (US) 2008-07-30 EP disclosed
EP-1945623-A2 POLYMORPHS OF 5-CYCLOPROPYL-2-(4-FLUOROPHENYL)-6-[(2-HYDROXYETHYL)(METHYLSULFONYL) AMINO]-N-METHYL-1-BENZOFURAN-3-CARBOXAMIDE AND METHODS OF MAKING THE SAME Wyeth a Corporation of the State of Delaware (US) 2008-07-23 EP disclosed
WO-2007059422-A2 PHARMACEUTICAL FORMULATIONS CONTAINING 5-CYCLOPROPYL-2(4-FLUOROPHENYL)-6-[(2-HYDROXYETHYL)(METHYLSULFONYL) AMINO]-N-METHYL-1-BENZOFURAN-3-CARBOXAMIDE AND METHOD OF MAKING SAME WYETH (US) 2007-05-24 WO disclosed
WO-2007059421-A2 POLYMORPHS OF 5-CYCLOPROPYL-2-(4-FLUOROPHENYL)-6-[(2-HYDROXYETHYL)(METHYLSULFONYL) AMINO]-N-METHYL-1-BENZOFURAN-3-CARBOXAMIDE AND METHODS OF MAKING THE SAME WYETH (US) 2007-05-24 WO disclosed