Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 11/20 | 0.77 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4606169 | 1.00 | GRIA4 (0.77) | GRIA4GRIA2MMP9MAPTMEN1 | |
| SCHEMBL4605315 | 0.89 | GRIA4 (0.65) | GRIA4GRIA2MAPTMEN1KMT2A | |
| SCHEMBL4605320 | 0.89 | GRIA4 (0.65) | GRIA4GRIA2MAPTMEN1KMT2A | |
| SCHEMBL4607627 | 0.87 | GRIA4 (1.00) | GRIA4GRIA2 | |
| SCHEMBL6575721 | 0.87 | GRIA4 (1.00) | GRIA4GRIA2 | |
| SCHEMBL4607083 | 0.87 | GRIA4 (0.60) | GRIA4GRIA2 | |
| SCHEMBL4606652 | 0.87 | GRIA4 (0.60) | GRIA4GRIA2 | |
| SCHEMBL4606558 | 0.87 | GRIA4 (0.60) | GRIA4GRIA2 | |
| SCHEMBL4606949 | 0.87 | GRIA4 (0.60) | GRIA4GRIA2 | |
| SCHEMBL4605406 | 0.86 | GRIA4 (0.59) | GRIA4GRIA2MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | claimed |
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |
| EP-1246797-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001042203-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |