Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 13/20 | 0.60 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4606652 | 1.00 | GRIA4 (0.60) | GRIA4GRIA2KCNH2ALDH1A1CACNA1B | |
| SCHEMBL4606558 | 0.91 | GRIA4 (0.60) | GRIA4GRIA2HDAC3HDAC11HDAC8 | |
| SCHEMBL4606949 | 0.91 | GRIA4 (0.60) | GRIA4GRIA2HDAC3HDAC11HDAC8 | |
| SCHEMBL4606846 | 0.90 | GRIA4 (0.74) | GRIA4GRIA2 | |
| SCHEMBL4607162 | 0.90 | GRIA4 (0.59) | GRIA4GRIA2POLB | |
| SCHEMBL4605406 | 0.90 | GRIA4 (0.59) | GRIA4GRIA2POLB | |
| SCHEMBL4606850 | 0.90 | GRIA4 (0.74) | GRIA4GRIA2 | |
| SCHEMBL4607600 | 0.90 | GRIA4 (0.70) | GRIA4GRIA2 | |
| SCHEMBL4607075 | 0.90 | GRIA4 (0.70) | GRIA4GRIA2 | |
| SCHEMBL4605831 | 0.90 | GRIA4 (0.55) | GRIA4GRIA2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | claimed |
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |