Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14140938 | 0.87 | CYP3A4 (0.42) | CYP3A4ELANEKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14141043 | 0.82 | CA12 (0.61) | CYP3A4ELANEKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4603952 | 0.81 | CYP3A4 (0.50) | CYP3A4KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL301499 | 0.81 | CYP3A4 (0.63) | CYP3A4KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL28367209 | 0.79 | KDM4E (0.48) | CYP3A4ELANEKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL22418858 | 0.76 | CYP3A4 (0.59) | CYP3A4KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL7756816 | 0.75 | CYP3A4 (0.72) | CYP3A4KMT2AMEN1ALDH1A1HTT | |
| SCHEMBL6689667 | 0.74 | CYP3A4 (0.61) | CYP3A4KMT2AMEN1SMN1; SMN2KDM4E | |
| Bicarbonate SCHEMBL3212051 | 0.74 | KDM4E (0.54) | CYP3A4ELANEKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL17509445 | 0.74 | CYP3A4 (0.49) | CYP3A4KMT2AMEN1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1944307-A2 | Synthetic Salicylihalamides, Apicularens and Derivatives Thereof | Board of Regents, The University of Texas System (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1944307-A2 | Synthetic Salicylihalamides, Apicularens and Derivatives Thereof | Board of Regents, The University of Texas System (US) | 2008-07-16 | — | — | EP | disclosed |
| US-6936723-B2 | Synthetic salicylihalamides, apicularens and derivatives thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2005-08-30 | — | — | US | disclosed |
| US-20040171672-A1 | Synthetic salicylihalamides, apicularens and derivatives thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2004-09-02 | — | — | US | disclosed |
| US-6734209-B2 | MACROCYCLIC LACTONES HAVING ANTI-CANCER ACTIVITY AND VACUOLAR ATPASE INHIBITORY ACTIVITY | BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM | 2004-05-11 | — | — | US | disclosed |
| US-20040063778-A1 | Synthetic salicylihalamides, apicularens and derivatives thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2004-04-01 | — | — | US | disclosed |
| US-6617348-B1 | Treating or preventing osteoporosis | UT SOUTHWESTERN MEDICAL CENTER | 2003-09-09 | — | — | US | disclosed |
| EP-1307439-A2 | SYNTHETIC SALICYLIHALAMIDES, APICULARENS AND DERIVATIVES THEREOF | Board of Regents, The University of Texas System (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012223-A2 | SYNTHETIC SALICYLIHALAMIDES, APICULARENS AND DERIVATIVES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063778-A1 | Synthetic salicylihalamides, apicularens and derivatives thereof | ATP6V1H, ATP6V1G1, ATP6V1A | CYP3A4 185/4885ELANE 4327/4885KMT2A 3382/4885 |
| US-20040171672-A1 | Synthetic salicylihalamides, apicularens and derivatives thereof | ATP6V1H, ATP6V1G1, ATP6V1A | CYP3A4 185/4885ELANE 4327/4885KMT2A 3382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.