Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27910271 | 0.91 | ALDH1A1 (0.50) | ALDH1A1MAPK1HTTMEN1KMT2A | |
| SCHEMBL801074 | 0.89 | ALDH1A1 (0.59) | ALDH1A1MAPK1HTTMEN1KMT2A | |
| SCHEMBL27910310 | 0.84 | ALDH1A1 (0.49) | ALDH1A1MAPK1HTTMEN1KMT2A | |
| SCHEMBL27741455 | 0.84 | ALDH1A1 (0.49) | ALDH1A1MAPK1HTTMEN1KMT2A | |
| SCHEMBL4752887 | 0.83 | ALDH1A1 (0.54) | ALDH1A1MAPK1HTTMEN1KMT2A | |
| SCHEMBL25199087 | 0.83 | HTT (0.64) | ALDH1A1MAPK1HTTMEN1KMT2A | |
| SCHEMBL3725533 | 0.83 | HTT (0.68) | ALDH1A1MAPK1HTTMEN1KMT2A | |
| SCHEMBL3171199 | 0.83 | MAPT (0.59) | ALDH1A1MAPK1HTTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4753957 | 0.82 | ALDH1A1 (0.52) | ALDH1A1MAPK1HTTMEN1KMT2A | |
| SCHEMBL27741463 | 0.82 | ALDH1A1 (0.39) | ALDH1A1MAPK1HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101296922-A | Kinase inhibitors | LILLY CO ELI (US) | 2008-10-29 | — | — | CN | disclosed |
| EP-1943243-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007053394-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-05-10 | — | — | WO | disclosed |