Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 13/20 | 0.65 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4606536 | 1.00 | GRIA4 (0.65) | GRIA4HCRTR2GRIA2ADRA2AADRA2B | |
| SCHEMBL4605901 | 0.85 | GRIA4 (0.67) | GRIA4HCRTR2GRIA2 | |
| SCHEMBL4607215 | 0.85 | GRIA4 (0.67) | GRIA4HCRTR2GRIA2 | |
| SCHEMBL14511723 | 0.83 | GRIA4 (0.70) | GRIA4HCRTR2GRIA2 | |
| SCHEMBL4606344 | 0.79 | GRIA4 (1.00) | GRIA4GRIA2 | |
| SCHEMBL4605907 | 0.79 | GRIA4 (1.00) | GRIA4GRIA2 | |
| SCHEMBL6573061 | 0.79 | GRIA4 (1.00) | GRIA4GRIA2 | |
| SCHEMBL4608018 | 0.79 | GRIA4 (1.00) | GRIA4GRIA2 | |
| SCHEMBL6573066 | 0.77 | GRIA4 (0.62) | GRIA4GRIA2 | |
| SCHEMBL4604595 | 0.76 | KDM1A (0.58) | GRIA4GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | claimed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | claimed |
| EP-1246797-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | claimed |
| WO-2001042203-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-14 | — | — | WO | claimed |
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |
| EP-1246797-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001042203-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |