Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 13/20 | 0.67 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.67 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4605901 | 1.00 | GRIA4 (0.67) | GRIA4GRIA2HCRTR2MAPK1HTT | |
| SCHEMBL4606538 | 0.85 | GRIA4 (0.65) | GRIA4GRIA2HCRTR2 | |
| SCHEMBL4606536 | 0.85 | GRIA4 (0.65) | GRIA4GRIA2HCRTR2 | |
| SCHEMBL4607668 | 0.80 | GRIA4 (1.00) | GRIA4GRIA2 | |
| SCHEMBL6554606 | 0.80 | GRIA4 (1.00) | GRIA4GRIA2 | |
| SCHEMBL4605805 | 0.80 | GRIA4 (1.00) | GRIA4GRIA2 | |
| SCHEMBL4608168 | 0.80 | GRIA4 (1.00) | GRIA4GRIA2 | |
| SCHEMBL4604595 | 0.74 | KDM1A (0.58) | GRIA4GRIA2MAPK1KDM1AMAOB | |
| SCHEMBL4604598 | 0.74 | KDM1A (0.58) | GRIA4GRIA2MAPK1KDM1AMAOB | |
| SCHEMBL14511723 | 0.68 | GRIA4 (0.70) | GRIA4GRIA2HCRTR2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | claimed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |