Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464217 | 0.85 | GPR119 (0.50) | — | |
| SCHEMBL4471364 | 0.85 | GPR119 (0.43) | SCDHTTCTSB | |
| SCHEMBL13708138 | 0.85 | SCD (0.42) | SCDCTSBKMT2ASMN1; SMN2 | |
| SCHEMBL4461393 | 0.84 | MAPT (0.51) | HTTCTSBALDH1A1MAPTKMT2A | |
| SCHEMBL4621578 | 0.81 | EPHX2 (0.39) | EPHX2HMOX1 | |
| SCHEMBL1776107 | 0.80 | AR (0.42) | SCDGAAHTTCTSBEPHX2 | |
| SCHEMBL4465119 | 0.80 | HRH1 (0.41) | SCDMAPTCYP2C9 | |
| SCHEMBL1775998 | 0.74 | AR (0.40) | SCDGAAHTTCTSBALDH1A1 | |
| SCHEMBL1775240 | 0.74 | AR (0.40) | SCDGAAHTTCTSBALDH1A1 | |
| SCHEMBL1775972 | 0.74 | AR (0.40) | SCDGAAHTTCTSBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943244-A1 | PYRAZOLE-ISOQUINOLINE UREA DERIVATIVES AS P38 KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007053346-A1 | PYRAZOLE-ISOQUINOLINE UREA DERIVATIVES AS P38 KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-05-10 | — | — | WO | disclosed |