Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL75332 | 0.81 | HRH3 (0.58) | POLBMAPTHRH3KCNH2MAOA | |
| SCHEMBL75477 | 0.80 | HRH3 (0.59) | POLBMAPTHRH3KCNH2MAOA | |
| SCHEMBL73535 | 0.77 | HRH3 (0.54) | POLBMAPTHRH3KCNH2MAOA | |
| SCHEMBL73863 | 0.77 | HRH3 (0.54) | POLBMAPTHRH3KCNH2MAOA | |
| SCHEMBL28995440 | 0.75 | CYP19A1 (0.40) | MAPTMAOBKDM4EALDH1A1 | |
| SCHEMBL4099964 | 0.75 | HRH3 (0.84) | POLBMAPTHRH3KCNH2HRH1 | |
| SCHEMBL4608619 | 0.74 | KDM4E (0.53) | HRH3KCNH2KDM4EALDH1A1HRH1 | |
| SCHEMBL31314460 | 0.73 | HRH3 (0.75) | POLBMAPTHRH3KCNH2MAOA | |
| SCHEMBL492263 | 0.72 | MEN1 (0.71) | POLBMAPTHRH3MAOAMAOB | |
| SCHEMBL12050718 | 0.71 | HRH3 (0.96) | HRH3KCNH2HRH1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945206-B1 | INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS | ATHERSYS INC (US) | 2013-04-24 | — | — | EP | disclosed |
| EP-1945206-A1 | INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS | Athersys, Inc. (US) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007047775-A1 | INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS | ATHERSYS, INC. (US) | 2007-04-26 | — | — | WO | disclosed |