Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4606822 | 0.74 | POLB (0.52) | KDM4EHRH3ALDH1A1HRH1KCNH2 | |
| SCHEMBL14970452 | 0.74 | HRH3 (0.89) | HRH3DRD3HRH1KCNH2 | |
| SCHEMBL492205 | 0.73 | HRH3 (0.84) | KDM4EHRH3DRD3ALDH1A1HRH1 | |
| SCHEMBL3576816 | 0.73 | KDM4E (0.61) | KDM4EL3MBTL1HRH3DRD3ALDH1A1 | |
| SCHEMBL21462645 | 0.72 | HRH3 (0.86) | KDM4EL3MBTL1HRH3ALDH1A1HRH1 | |
| SCHEMBL4084100 | 0.71 | HRH3 (0.87) | KDM4EHRH3ALDH1A1HRH1SMN1; SMN2 | |
| SCHEMBL2823877 | 0.71 | HRH3 (0.87) | KDM4EHRH3ALDH1A1HRH1SMN1; SMN2 | |
| SCHEMBL3996964 | 0.71 | DRD3 (0.49) | KDM4EHRH3DRD3ALDH1A1HRH1 | |
| SCHEMBL7959785 | 0.71 | KDM4E (0.67) | KDM4EL3MBTL1HRH3ALDH1A1TSHR | |
| SCHEMBL17372602 | 0.71 | LTA4H (0.70) | KDM4EL3MBTL1HRH3ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945206-A1 | INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS | Athersys, Inc. (US) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007047775-A1 | INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS | ATHERSYS, INC. (US) | 2007-04-26 | — | — | WO | disclosed |