Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.37 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4607033 | 1.00 | GLS (0.37) | GLSPTPN11ABHD6AKR1C3HTR2C | |
| SCHEMBL4968634 | 0.88 | AKR1C3 (0.49) | GLSPTPN11ABHD6AKR1C3AOC3 | |
| SCHEMBL4968622 | 0.88 | AKR1C3 (0.49) | GLSPTPN11ABHD6AKR1C3AOC3 | |
| SCHEMBL4218392 | 0.86 | MEN1 (0.42) | PTPN11AKR1C3AOC3KDM4EPLA2G4A | |
| SCHEMBL1400796 | 0.85 | PDK2 (0.32) | AKR1C3HTR2CSLC6A4KDM4E | |
| SCHEMBL1400797 | 0.85 | PDK2 (0.32) | AKR1C3HTR2CSLC6A4KDM4E | |
| SCHEMBL4211969 | 0.83 | HSD17B2 (0.47) | PTPN11AOC3NLRP3 | |
| SCHEMBL4361055 | 0.82 | KDM4E (0.38) | PTPN11AKR1C3KDM4E | |
| SCHEMBL4361050 | 0.82 | KDM4E (0.38) | PTPN11AKR1C3KDM4E | |
| SCHEMBL4213898 | 0.82 | HSD17B2 (0.46) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943213-A2 | PPAR MODULATING BIAROMATIC COMPOUNDS | Galderma Research & Development (FR) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007049158-A2 | PPAR MODULATING BIAROMATIC COMPOUNDS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2007-05-03 | — | — | WO | disclosed |