Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5751970 | 0.82 | HRH3 (0.48) | HRH3ACHERAD52 | |
| SCHEMBL5753560 | 0.70 | HRH3 (0.49) | HRH3L3MBTL1ACHERAD52HRH1 | |
| SCHEMBL2827364 | 0.67 | HRH3 (0.75) | HRH3KDM4EL3MBTL1ACHERAD52 | |
| SCHEMBL10200146 | 0.67 | HRH3 (0.75) | HRH3KDM4EL3MBTL1ACHERAD52 | |
| SCHEMBL7442447 | 0.67 | MEN1 (0.46) | HRH3ALDH1A1KDM4EL3MBTL1CYP2D6 | |
| SCHEMBL3581930 | 0.67 | HRH3 (0.89) | HRH3L3MBTL1ACHERAD52HRH1 | |
| SCHEMBL25997033 | 0.66 | L3MBTL1 (0.54) | HRH3ALDH1A1KDM4EL3MBTL1CYP2D6 | |
| SCHEMBL23804894 | 0.65 | HRH3 (0.77) | HRH3ALDH1A1ACHERAD52HRH1 | |
| SCHEMBL2629440 | 0.65 | HRH3 (0.72) | HRH3KDM4EL3MBTL1ACHERAD52 | |
| SCHEMBL491935 | 0.65 | HRH3 (0.88) | HRH3ACHERAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945206-A1 | INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS | Athersys, Inc. (US) | 2008-07-23 | — | — | EP | claimed |
| WO-2007047775-A1 | INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS | ATHERSYS, INC. (US) | 2007-04-26 | — | — | WO | claimed |