Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | CTSG | P08311 | 1/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3066768 | 1.00 | CNR2 (0.51) | CNR2CTSGCTRB1SMN1; SMN2KMT2A | |
| SCHEMBL23201144 | 1.00 | CNR2 (0.51) | CNR2CTSGCTRB1SMN1; SMN2KMT2A | |
| SCHEMBL4906710 | 0.87 | TRPA1 (0.49) | — | |
| SCHEMBL15958711 | 0.86 | SMN1; SMN2 (0.50) | CNR2CTSGCTRB1SMN1; SMN2KMT2A | |
| SCHEMBL1177054 | 0.83 | HTT (0.51) | CNR2CTSGCTRB1SMN1; SMN2KMT2A | |
| SCHEMBL3959317 | 0.81 | MAPK1 (0.68) | CTRB1KMT2AMEN1CYP3A4MAPK1 | |
| SCHEMBL3897966 | 0.81 | MAPK1 (0.68) | CTRB1KMT2AMEN1CYP3A4MAPK1 | |
| SCHEMBL2973301 | 0.81 | MAPK1 (0.68) | CTRB1KMT2AMEN1CYP3A4MAPK1 | |
| SCHEMBL23120332 | 0.81 | SMN1; SMN2 (0.49) | CNR2CTSGCTRB1SMN1; SMN2KMT2A | |
| SCHEMBL14350867 | 0.81 | SMN1; SMN2 (0.49) | CNR2CTSGCTRB1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466678-B | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH CORP | 2012-12-26 | — | — | CN | disclosed |
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |