Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL28879602 | 0.82 | TSHR (0.53) | TSHRNAPRTTDP1ALDH1A1CYP2D6 | |
| Pyridine SCHEMBL27955391 | 0.81 | TDP1 (0.69) | TSHRNAPRTTDP1ALDH1A1POLB | |
| Pyridine SCHEMBL17504474 | 0.81 | — | — | |
| Benzene SCHEMBL203064 | 0.80 | TP53 (0.73) | TSHRTP53HTTCYP1A2MEN1 | |
| Pyridine SCHEMBL29244254 | 0.80 | TSHR (0.50) | TSHRNAPRTTDP1CYP1A2CYP2D6 | |
| Pyridine SCHEMBL8084663 | 0.78 | TSHR (0.47) | TSHRNAPRTTDP1ALDH1A1NPSR1 | |
| Pyridine SCHEMBL27871778 | 0.78 | TDP1 (0.64) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL242310 | 0.78 | TDP1 (0.64) | TSHRNAPRTTDP1ALDH1A1CYP2D6 | |
| Benzene SCHEMBL8038038 | 0.77 | TP53 (0.67) | TSHRTP53HTTCYP1A2MAPT | |
| Pyridine SCHEMBL8097855 | 0.75 | TDP1 (0.60) | TSHRNAPRTTDP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114539244-A | Preparation method of moxifloxacin hydrochloride | 沈阳药科大学 | 2022-05-27 | — | — | CN | claimed |
| CN-109400720-A | A kind of preparation method and application of amphoteric cellulose adsorbent | 信阳师范学院 | 2019-03-01 | — | — | CN | claimed |
| CN-114539244-B | Preparation method of moxifloxacin hydrochloride | 沈阳药科大学 | 2023-04-14 | — | — | CN | disclosed |
| CN-114539244-A | Preparation method of moxifloxacin hydrochloride | 沈阳药科大学 | 2022-05-27 | — | — | CN | disclosed |
| CN-109790153-A | Plant with increased herbicide tolerant | 巴斯夫农业公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-109400720-A | A kind of preparation method and application of amphoteric cellulose adsorbent | 信阳师范学院 | 2019-03-01 | — | — | CN | disclosed |
| CN-109400720-A | A kind of preparation method and application of amphoteric cellulose adsorbent | 信阳师范学院 | 2019-03-01 | — | — | CN | disclosed |
| US-7456292-B2 | Hydroxamic acid-containing amino acid derivatives | BEXEL PHARMACEUTICALS, INC. (US) | 2008-11-25 | — | — | US | disclosed |
| EP-1907352-A2 | NOVEL DERIVATIVES OF AMINO ACIDS FOR TREATMENT OF OBESITY AND RELATED DISORDERS | Bexel Pharmaceuticals Inc (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007005774-A9 | NOVEL DERIVATIVES OF AMINO ACIDS FOR TREATMENT OF OBESITY AND RELATED DISORDERS | BEXEL PHARMACEUTICALS INC (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007005774-A2 | NOVEL DERIVATIVES OF AMINO ACIDS FOR TREATMENT OF OBESITY AND RELATED DISORDERS | BEXEL PHARMACEUTICALS, INC. (US) | 2007-01-11 | — | — | WO | disclosed |
| US-20070004776-A1 | Novel hydroxamic acid-containing amino acid derivatives | BEXEL PHARMACEUTICALS, INC. | 2007-01-04 | — | — | US | disclosed |
| US-6610412-B2 | Clear protective thermal transfer overcoating and acrylic polymer compatibilizer; computer prints | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. | 2003-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004776-A1 | Novel hydroxamic acid-containing amino acid derivatives | HGFAC, HCAR2, BCAT1 | TSHR 1956/4885NAPRT 1232/4885TDP1 3873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.