Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3259829 | 0.88 | TSHR (0.68) | TSHRPOLBMAPK1HTTMAPT | |
| SCHEMBL4608066 | 0.84 | TSHR (0.58) | TSHRPOLBMAPK1HTTMAPT | |
| SCHEMBL4608240 | 0.78 | TXNRD1 (0.60) | TSHRPOLBMAPK1HTTMAPT | |
| SCHEMBL30184665 | 0.76 | SMN1; SMN2 (0.59) | TSHRPOLBMAPK1HTTMAPT | |
| SCHEMBL358860 | 0.76 | SMN1; SMN2 (0.59) | TSHRPOLBMAPK1HTTMAPT | |
| SCHEMBL30291384 | 0.76 | MAPT (0.55) | TSHRPOLBMAPK1HTTMAPT | |
| SCHEMBL8777970 | 0.76 | MAPT (0.55) | TSHRPOLBMAPK1HTTMAPT | |
| SCHEMBL14988893 | 0.75 | MAPT (0.54) | TSHRPOLBMAPK1HTTMAPT | |
| SCHEMBL14988892 | 0.75 | MAPT (0.54) | TSHRPOLBMAPK1HTTMAPT | |
| SCHEMBL155420 | 0.75 | MAPT (0.54) | TSHRPOLBMAPK1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1059927-B1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | disclosed |
| US-6369273-B1 | ARYL ALCOHOLS OR ESTERS FOR ELEVATION OF PYRUVATE DHYDROGENASE | ASTRAZENECA AB (SE) | 2002-04-09 | — | — | US | disclosed |
| EP-0617010-B1 | Therapeutic compounds | ASTRAZENECA AB (SE) | 2002-01-09 | — | — | EP | disclosed |
| EP-1059927-A1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | AstraZeneca AB (SE) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999044618-A1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 1999-09-10 | — | — | WO | disclosed |
| US-5900432-A | Therapeutic N-(4-benzoyl-2-methyl-phenyl)-3,3,3-trifluoro-2-hydroxy-2-methyl-propanamides | ZENECA LIMITED (GB) | 1999-05-04 | — | — | US | disclosed |
| US-5482969-A | Certain N(4-benzoyl-2-phenyl)-3- trifluoro-2-hydroxy-propanamide derivatives | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| EP-0617010-A1 | Therapeutic compounds | ZENECA LIMITED (GB) | 1994-09-28 | — | — | EP | disclosed |