Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1855939 | 0.89 | KMT2A (0.39) | KDM4EKMT2AMEN1ALDH1A1LMNA | |
| Piperazine SCHEMBL28277891 | 0.82 | — | — | |
| SCHEMBL23095701 | 0.82 | KMT2A (0.35) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL538775 | 0.81 | MEN1 (0.34) | KMT2AMEN1 | |
| SCHEMBL5731936 | 0.81 | MEN1 (0.34) | KMT2AMEN1 | |
| SCHEMBL1473655 | 0.81 | MEN1 (0.34) | KMT2AMEN1 | |
| SCHEMBL13076980 | 0.77 | — | — | |
| SCHEMBL11428307 | 0.75 | KMT2A (0.36) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL446210 | 0.73 | ALDH1A1 (0.37) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL4912844 | 0.72 | KMT2A (0.36) | KDM4EGAACYP2C9KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694795-B2 | SYSTEM FOR BONDING GLASS INTO A STRUCTURE | DOW GLOBAL TECHNOLOGIES LLC (US) | 2016-03-30 | — | — | EP | disclosed |
| EP-2782943-A1 | CURABLE COMPOSITIONS CONTAINING ISOCYANATE FUNCTIONAL COMPONENTS AND HAVING IMPROVED DURABILITY IN THE CURED STATE | Dow Global Technologies LLC (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013077908-A1 | CURABLE COMPOSITIONS CONTAINING ISOCYANATE FUNCTIONAL COMPONENTS AND HAVING IMPROVED DURABILITY IN THE CURED STATE | DOW GLOBAL TECHNOLOGIES LLC (US) | 2013-05-30 | — | — | WO | disclosed |
| EP-1694795-B1 | SYSTEM FOR BONDING GLASS INTO A STRUCTURE | DOW GLOBAL TECHNOLOGIES INC (US) | 2008-07-23 | — | — | EP | disclosed |