Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 5/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571419 | 0.89 | ALDH1A1 (0.55) | PDE7AL3MBTL1ALDH1A1TDP1LMNA | |
| SCHEMBL2904377 | 0.85 | ALDH1A1 (0.56) | PDE7APDE7BL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL310270 | 0.81 | CYP11B1 (0.59) | L3MBTL1KMT2AALDH1A1TDP1LMNA | |
| SCHEMBL14993876 | 0.79 | ALDH1A1 (0.53) | L3MBTL1ALDH1A1TDP1LMNAPOLB | |
| SCHEMBL11860085 | 0.78 | PDE7A (0.55) | PDE7APDE4BPDE4DPDE7BKMT2A | |
| SCHEMBL20727289 | 0.78 | PDE7A (0.55) | PDE7APDE4BPDE4DPDE7BKMT2A | |
| SCHEMBL6088806 | 0.75 | MAPT (0.51) | PDE7AL3MBTL1KMT2AALDH1A1TDP1 | |
| SCHEMBL11730953 | 0.75 | PDE7A (0.51) | PDE7APDE4BPDE4DPDE7BKMT2A | |
| SCHEMBL5859807 | 0.74 | PDE7A (0.61) | PDE7AL3MBTL1ALDH1A1TDP1LMNA | |
| SCHEMBL5858624 | 0.74 | TDP1 (0.48) | PDE7AL3MBTL1ALDH1A1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1059927-B1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | disclosed |
| US-6369273-B1 | ARYL ALCOHOLS OR ESTERS FOR ELEVATION OF PYRUVATE DHYDROGENASE | ASTRAZENECA AB (SE) | 2002-04-09 | — | — | US | disclosed |
| EP-0617010-B1 | Therapeutic compounds | ASTRAZENECA AB (SE) | 2002-01-09 | — | — | EP | disclosed |
| EP-1059927-A1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | AstraZeneca AB (SE) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999044618-A1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 1999-09-10 | — | — | WO | disclosed |
| US-5900432-A | Therapeutic N-(4-benzoyl-2-methyl-phenyl)-3,3,3-trifluoro-2-hydroxy-2-methyl-propanamides | ZENECA LIMITED (GB) | 1999-05-04 | — | — | US | disclosed |
| US-5482969-A | Certain N(4-benzoyl-2-phenyl)-3- trifluoro-2-hydroxy-propanamide derivatives | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| EP-0617010-A1 | Therapeutic compounds | ZENECA LIMITED (GB) | 1994-09-28 | — | — | EP | disclosed |