Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | MPL | P40238 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 9/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836500 | 0.78 | MEN1 (0.41) | IDO1CYP1A2 | |
| SCHEMBL3713639 | 0.77 | FEN1 (0.53) | KDM1AMPLMAOBFEN1ALOX5AP | |
| SCHEMBL20322968 | 0.71 | KDM1A (0.53) | KDM1AMAOBIDO1TRPV1 | |
| SCHEMBL31706466 | 0.70 | IDO1 (0.43) | MAOBIDO1 | |
| SCHEMBL18586785 | 0.68 | KDM1A (0.45) | KDM1AMPLFEN1ALOX5APCYP1A2 | |
| SCHEMBL12708057 | 0.67 | IDO1 (0.43) | MAOBIDO1 | |
| SCHEMBL29037326 | 0.66 | IDO1 (0.37) | MPLMAOBIDO1 | |
| SCHEMBL5466506 | 0.66 | TRPV1 (0.41) | MAOBIDO1TRPV1CYP1A2 | |
| Hydrochloric Acid SCHEMBL15021921 | 0.66 | KCNA5 (0.43) | MPLMAOBFEN1ALOX5APIDO1 | |
| SCHEMBL18587146 | 0.65 | KDM1A (0.51) | KDM1AMPLMAOBFEN1ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885723-A2 | PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2007013896-A2 | PYRROL (2,3-B) PYRIDINE DERIVATIVES PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-02-01 | — | — | WO | disclosed |