Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL462881 | 0.90 | NTRK1 (0.66) | NTRK1 | |
| SCHEMBL10280193 | 0.89 | NTRK1 (0.49) | NTRK1 | |
| SCHEMBL432863 | 0.89 | NTRK1 (0.49) | NTRK1 | |
| SCHEMBL461550 | 0.85 | NTRK1 (0.64) | NTRK1 | |
| SCHEMBL460750 | 0.81 | NTRK1 (0.61) | NTRK1 | |
| SCHEMBL431818 | 0.78 | NTRK1 (0.56) | NTRK1 | |
| SCHEMBL23761805 | 0.78 | NTRK1 (0.45) | NTRK1 | |
| SCHEMBL12504925 | 0.77 | NTRK1 (0.67) | NTRK1 | |
| SCHEMBL23692444 | 0.77 | NTRK1 (0.45) | NTRK1 | |
| SCHEMBL464621 | 0.77 | NTRK1 (0.69) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614062-A1 | IMIDAZO [1, 2]PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2013-07-17 | — | — | EP | claimed |
| WO-2012034091-A1 | IMIDAZO [1, 2] PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | claimed |