Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.66 |
| ▸ | NTRK3 | Q16288 | 5/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
| ▸ | ROS1 | P08922 | 1/20 | 0.55 |
| ▸ | FGR | P09769 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.55 |
| ▸ | TIE1 | P35590 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL461550 | 0.94 | NTRK1 (0.64) | NTRK1NTRK3NTRK2JAK2INSR | |
| SCHEMBL460750 | 0.91 | NTRK1 (0.61) | NTRK1NTRK3NTRK2JAK2INSR | |
| SCHEMBL460886 | 0.90 | NTRK1 (0.57) | NTRK1 | |
| SCHEMBL431818 | 0.88 | NTRK1 (0.56) | NTRK1NTRK3NTRK2JAK2INSR | |
| SCHEMBL12504925 | 0.86 | NTRK1 (0.67) | NTRK1NTRK3NTRK2JAK2INSR | |
| SCHEMBL460616 | 0.86 | NTRK1 (0.59) | NTRK1NTRK3NTRK2JAK2INSR | |
| SCHEMBL433442 | 0.86 | NTRK1 (0.69) | NTRK1NTRK3NTRK2JAK2INSR | |
| SCHEMBL464621 | 0.86 | NTRK1 (0.69) | NTRK1NTRK3NTRK2JAK2INSR | |
| SCHEMBL462312 | 0.85 | NTRK1 (0.58) | NTRK1NTRK3NTRK2JAK2INSR | |
| SCHEMBL433590 | 0.85 | NTRK1 (0.55) | NTRK1NTRK3NTRK2JAK2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614062-A1 | IMIDAZO [1, 2]PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2013-07-17 | — | — | EP | claimed |
| WO-2012034091-A1 | IMIDAZO [1, 2] PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | claimed |